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Combo-pilling is the newest fad or also the newest ahead under scrutiny and thus it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills has become popular may be the fact that since right now there are no long term prescription weight loss supplements that have been licensed by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug could also raise hypertension and pulse rate, and must not be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure levels and heart rate and must not used in patients with uncontrolled high hypertension, along with by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients on the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation. Approving a drug with this many potentially lethal negative effects is inconsistent while using mission statement with the FDA. The power with the drug manufacturing lobby is blatantly evident inside the approval of several drugs requiring 'post-marketing' studies which can be clearly significant to overall drug safety in the US.
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