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Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which can be made up of more than one active ingredient, which may make them more effective and safer. Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular may be the fact that since right now there aren't long term prescription weightloss pills that have been authorized by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug may also raise hypertension and heartbeat, and must not be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must stop used in patients with uncontrolled high blood pressure level, in addition to by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients towards the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking. New UCLA study on smokers with mental, drug, and alcohol problems
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