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Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not used in patients with uncontrolled high hypertension, as well as by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients with a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients towards the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. Acamprosate also works to eliminate the want to drink by reducing the the cravings for alcohol consumption. The major difference between Naltrexone and Acamprosate is that Acamprosate is not yet accessible in the United States. While it has been widely studied in Europe the precise chemical reason why it works continues to be unknown. It is belief that it disrupts receptors inside the brain which process glutamate, which in effect alters the best way ones body reacts to alcohol intake. Several of the European research shows a lot of promise with Acamprosate in this some of the patients had a practically double success rate for staying sober.
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