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Seizures certainly are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug can also raise blood pressure level and heartrate, and really should not be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must not used in patients with uncontrolled high blood pressure levels, as well as by you are not heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients with a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking. "This will be the first drug I'm aware of that targets the appetite and reward centres within the brain," he was quoted saying.

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